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Regorafenib monohydrate
CAS No. 1019206-88-2
Regorafenib monohydrate ( BAY 73-4506 monohydrate )
产品货号. M10092 CAS No. 1019206-88-2
A potent multikinase inhibitor that potently inhibits these endothelial cell kinases in biochemical and cellular kinase phosphorylation assays.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥251 | 有现货 |
|
| 50MG | ￥729 | 有现货 |
|
| 100MG | ￥1158 | 有现货 |
|
| 200MG | ￥1766 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Regorafenib monohydrate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent multikinase inhibitor that potently inhibits these endothelial cell kinases in biochemical and cellular kinase phosphorylation assays.
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产品描述A potent multikinase inhibitor that potently inhibits these endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM); inhibits VEGFR1/2/3, PDGFRβ, FGFR1, KIT, RET and B-RAF etc.; exhibits potent dose-dependent TGI in various preclinical human xenograft models in mice; orally active.Colon Cancer Approved
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同义词BAY 73-4506 monohydrate
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通路Angiogenesis
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靶点VEGFR
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受体VEGFR
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研究领域Cancer
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适应症Colon Cancer
化学信息
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CAS Number1019206-88-2
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分子量500.83
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分子式C21H17ClF4N4O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F.O
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化学全称2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrate (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wilhelm SM, et al. Int J Cancer. 2011 Jul 1;129(1):245-55.
2. Mross K, et al. Clin Cancer Res. 2012 May 1;18(9):2658-67.
3. Abou-Elkacem L, et al. Mol Cancer Ther. 2013 Jul;12(7):1322-31.
2. Mross K, et al. Clin Cancer Res. 2012 May 1;18(9):2658-67.
3. Abou-Elkacem L, et al. Mol Cancer Ther. 2013 Jul;12(7):1322-31.
产品手册
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Regorafenib monohydr...
A potent multikinase inhibitor that potently inhibits these endothelial cell kinases in biochemical and cellular kinase phosphorylation assays.
